Unlike the previous wives of Philip, Cristina had a quite adventurous life (and a lot of sufferance) before marrying him as their wedding was the third for both of them…
As she was the younger daughter of a deposed King, in normal circumstance Cristina would have difficulty in finding a good match, but she had the advantage of being Charles V’s niece and that meant who after their father’s deposition, she and her elder sister Dorothea were raised in the Burgundian lands and would become matrimonial pawns for the Emperor: Dorothea would marry the Elector Palatine in 1535 in a match who would remain childless, while Cristina had already married the Duke of Milan in 1533, when she was barely 12 years old, but the match would never be consummated as Francesco Sforza would die before the 14th birthday of Cristina.
As the Duchy would go back to Emperor for the extinction of the legitimate male line of Ludovico Sforza, Cristina was free to remain there and so she would take her time before returning to the Netherlands… Various matches were prospected to Cristina before the Emperor dictated her remarriage to the Duke of Lorraine in 1541.
This second wedding, like her first one, was happy but short as Francis of Lorraine would die in 1545, leaving Cristina as a widow with three small children (a two years old boy, Charles, who would follow his father as Duke of Lorraine, and two girls Renata and Dorothea) in a difficult position. While her husband had left her as regent for their son, the Estates of Lorraine seeing her as a puppet of the Emperor forced her to share the regency with her brother-in-law Nicholas of Mercoeur, who was more friendly to France. At the beginning of 1552 the King of France, after assuring Cristina who he would have respected the neutrality of Lorraine, instead attacked the Duchy, entering in Nancy, were he informed Cristina who not only she had lost the custody of her son, who would go with the King of France as he would be raised in Paris as his ward, but she was also deprived of any role in the regency and would have to left the Duchy, like all the imperial officers.
Cristina was desperate but unable to do anything, except taking her daughters and search refuge at her sister‘s court before returning in the Netherlands, together with her sister-in-law Anne and the latter’s daughter, Maria of Châlon, Princess of Orange (who would eventually marry Karl of Julich-Cleves-Berg, four years younger than her and son of a cousin of Cristina), under the protection of her uncle, who had recently established his main seat there (with frequent visits in his wife’s kingdom over the water) and were her aunts Eleanor and Mary would comfort her. Cristina had refused many offers of marriage after her second husband‘s death as she had no intention to remarry again, but few months after her arrival in the Netherlands she would catch the interest of her cousin Philip, recently widowed, who at 25 years old and with four kingdoms to rule needed a new wife, as the support of his sister Joanna was not enough for him. Cristina deeply fascinated him and the fact who she was already in her 30’s was not seen as a big disadvantage: she was his cousin, was smart and brilliant, and while Emperor Charles would have liked seeing more children of Philip between his English children and the Spanish crown, Philip‘s priority was give a loving stepmother and a stable family to his children and in any case he had already three sons and Cristina was not too old for giving him more children.
Cristina, after an initial refusal, in the end would reluctantly accept Philip’s suit, under the pressure of her uncle and aunts, and would not regret it, as she would find again happiness in Spain, with her daughters, her four stepchildren and would give two more children to Philip: a daughter, Isabella Clara Eugenia, and a son who would be called Ferdinand, who in the end would become unexpectedly King of Spain jure-uxoris, after marring his half-niece…
Cristina would be able to see again her son only once, after he had married a daughter of the French King, but she and Felipe would have a loving marriages and she would quickly become his most trusted advisor, with her sister-in-law Juana just behind her in that role…